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1

Malaria

Phillips, Margaret A., Burrows, Jeremy N., Manyando, Christine, van Huijsduijnen, Rob Hooft, Van Voorhis, Wesley C., Wells, Timothy N. C.

Journal:

Nature Reviews Disease Primers

Year:

2017

Language:

english

File:

PDF, 2.97 MB

english, 2017

2

Hit and lead criteria in drug discovery for infectious diseases of the developing world

Katsuno, Kei, Burrows, Jeremy N., Duncan, Ken, van Huijsduijnen, Rob Hooft, Kaneko, Takushi, Kita, Kiyoshi, Mowbray, Charles E., Schmatz, Dennis, Warner, Peter, Slingsby, B. T.

Journal:

Nature Reviews Drug Discovery

Year:

2015

Language:

english

File:

PDF, 274 KB

english, 2015

3

Profile of William C. Campbell, Satoshi Ōmura, and Youyou Tu, 2015 Nobel Laureates in Physiology or Medicine

Van Voorhis, Wesley C., Hooft van Huijsduijnen, Rob, Wells, Timothy N. C.

Journal:

Proceedings of the National Academy of Sciences

Year:

2015

Language:

english

File:

PDF, 1.12 MB

english, 2015

4

Open data in drug discovery and development: lessons from malaria

Wells, Timothy N. C., Willis, Paul, Burrows, Jeremy N., van Huijsduijnen, Rob Hooft

Journal:

Nature Reviews Drug Discovery

Year:

2016

Language:

english

File:

PDF, 122 KB

english, 2016

5

A Phase II pilot trial to evaluate safety and efficacy of ferroquine against early Plasmodium falciparum in an induced blood-stage malaria infection study

McCarthy, James S., Rückle, Thomas, Djeriou, Elhadj, Cantalloube, Cathy, Ter-Minassian, Daniel, Baker, Mark, O’Rourke, Peter, Griffin, Paul, Marquart, Louise, Hooft van Huijsduijnen, Rob, Möhrle, Jörg

Journal:

Malaria Journal

Year:

2016

Language:

english

File:

PDF, 1.05 MB

english, 2016

6

A discovery and development roadmap for new endectocidal transmission-blocking agents in malaria

Burrows, Jeremy, Slater, Hannah, Macintyre, Fiona, Rees, Sarah, Thomas, Anna, Okumu, Fredros, Hooft van Huijsduijnen, Rob, Duparc, Stephan, Wells, Timothy N. C.

Journal:

Malaria Journal

Year:

2018

Language:

english

File:

PDF, 2.82 MB

english, 2018

7

Mapping and identification of protein-protein interactions by two-dimensional far-Western immunoblotting

Christian Pasquali, Francis Vilbois, Marie-Laure Curchod, Rob Hooft van Huijsduijnen, Fabrizio Arigoni

Journal:

ELECTROPHORESIS

Year:

2000

Language:

english

File:

PDF, 766 KB

english, 2000

8

Prospects for Inhibitors of Protein Tyrosine Phosphatase 1B as Antidiabetic Drugs.

Rob Hooft van Huijsduijnen, Wolfgang H. B. Sauer, Agnes Bombrun, Dominique Swinnen

Journal:

Year:

2004

File:

PDF, 10 KB

2004

9

Characterization of protein tyrosine phosphatase H1 knockout mice in animal models of local and systemic inflammation

Claudia Patrignani, David T Lafont, Valeria Muzio, Béatrice Gréco, Rob Hooft van Huijsduijnen, Paola F Zaratin

Journal:

Journal of Inflammation

Year:

2010

Language:

english

File:

PDF, 1.28 MB

english, 2010

10

Homology between chitinases that are induced by TMV infection of tobacco

R. A. M. Hooft van Huijsduijnen, S. Kauffmann, F. Th. Brederode, B. J. C. Cornelissen, M. Legrand, B. Fritig, J. F. Bol

Journal:

Plant Molecular Biology

Year:

1987

Language:

english

File:

PDF, 1.51 MB

english, 1987

11

Decompartmentalizing target validation—thinking outside thepipelineboxes

Rob Hooft van Huijsduijnen, Christian Rommel

Journal:

Journal of Molecular Medicine

Year:

2006

Language:

english

File:

PDF, 358 KB

english, 2006

12

Protein tyrosine phosphatases in glioma biology

Anna C. Navis, Monique van den Eijnden, Jan T. G. Schepens, Rob Hooft van Huijsduijnen, Pieter Wesseling, Wiljan J. A. J. Hendriks

Journal:

Acta Neuropathologica

Year:

2010

Language:

english

File:

PDF, 468 KB

english, 2010

13

Hypothalamic Neuropeptide Y Messenger Ribonucleic Acid Levels in Pre-Obese and Genetically Obese (fa/fa) Rats; Potential Regulation Thereof by Corticotropin-Releasing Factor

OlfaBchini-Hooft van Huijsduijnen, Françoise Rohner-Jeanrenaud, Bernard Jeanrenaud

Journal:

Journal of Neuroendocrinology

Year:

1993

Language:

english

File:

PDF, 911 KB

english, 1993

14

Protein tyrosine phosphatases: dual-specificity phosphatases in health and disease

Rafael Pulido, Rob Hooft van Huijsduijnen

Journal:

Year:

2008

Language:

english

File:

PDF, 478 KB

english, 2008

15

A tobacco mosaic virus-induced tobacco protein is homologous to the sweet-tasting protein thaumatin

Cornelissen, Ben J. C., Hooft van Huijsduijnen, Rob A. M., Bol, John F.

Journal:

Year:

1986

File:

PDF, 251 KB

1986

16

Highly controlled gene expression using combinations of a tissue-specific promoter, recombinant adenovirus and a tetracycline-regulatable transcription factor

Ghersa, P, Gobert, R Pescini, Sattonnet-Roche, P, Richards, C A, Merlo Pich, E, Hooft van Huijsduijnen, R

Journal:

Year:

1998

Language:

english

File:

PDF, 273 KB

english, 1998

17

The SPOT technique as a tool for studying protein tyrosine phosphatase substrate specificities

Xavier Espanel, Martine Huguenin-Reggiani, Rob Hooft van Huijsduijnen

Journal:

Protein Science

Year:

2002

Language:

english

File:

PDF, 391 KB

english, 2002

18

Prospects for Inhibitors of Protein Tyrosine Phosphatase 1B as Antidiabetic Drugs

Hooft van Huijsduijnen, Rob, Sauer, Wolfgang H. B., Bombrun, Agnes, Swinnen, Dominique

Journal:

Journal of Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 188 KB

english, 2004

19

Intracellular substrates of brain-enriched receptor protein tyrosine phosphatase rho (RPTPρ/PTPRT)

Julie A. Besco, Rob Hooft van Huijsduijnen, Adrienne Frostholm, Andrej Rotter

Journal:

Year:

2006

Language:

english

File:

PDF, 647 KB

english, 2006

20

Structural Basis for Selective Inhibition of Mycobacterium tuberculosis Protein Tyrosine Phosphatase PtpB

Christoph Grundner, Dominique Perrin, Rob Hooft van Huijsduijnen, Dominique Swinnen, Jérome Gonzalez, Christine L. Gee, Timothy N. Wells, Tom Alber

Journal:

Year:

2007

Language:

english

File:

PDF, 1.44 MB

english, 2007

21

Selecting protein tyrosine phosphatases as drug targets

Rob Hooft van Huijsduijnen, Agnes Bombrun, Dominique Swinnen

Journal:

Drug Discovery Today

Year:

2002

Language:

english

File:

PDF, 305 KB

english, 2002

22

Monitor – Biology

Herman H Cheung, Marieke Kruidering, Christian G Noble, David J Miller, Matt J Barnes, George F Gao, Mattias Collin, Shawn Chen, Rob Hooft van Huijsduijnen

Journal:

Drug Discovery Today

Year:

2004

Language:

english

File:

PDF, 64 KB

english, 2004

23

Biology

Burkhard Haefner, Roy M Golsteyn, Michael R Seringhaus, Rob Hooft van Huijsduijnen, Olfa Hooft van Huijsduijnen, Leodevico L Ilag, Alex Gaither, Victoria Heath, Dipak K Sarker

Journal:

Drug Discovery Today

Year:

2004

Language:

english

File:

PDF, 69 KB

english, 2004

24

Commonly used cat reporter vectors contain a cAMP-inducible, cryptic enhancer that co-operates with NF-KB-sites

Paola Ghersa, James Whelan, Rosanna Pescini, John F. DeLamarter, Rob Hooft van Huijsduijnen

Journal:

Year:

1994

Language:

english

File:

PDF, 208 KB

english, 1994

25

Sap-1/PTPRH activity is regulated by reversible dimerization

Sébastien Wälchli, Xavier Espanel, Rob Hooft van Huijsduijnen

Journal:

Biochemical and Biophysical Research Communications

Year:

2005

Language:

english

File:

PDF, 263 KB

english, 2005

26

The protein tyrosine phosphatase PTPN4/PTP-MEG1, an enzyme capable of dephosphorylating the TCR ITAMs and regulating NF-κB, is dispensable for T cell development and/or T cell effector functions

Jennifer A. Young, Amy M. Becker, Jennifer J. Medeiros, Virginia S. Shapiro, Andrew Wang, J. David Farrar, Timothy A. Quill, Rob Hooft van Huijsduijnen, Nicolai S.C. van Oers

Journal:

Molecular Immunology

Year:

2008

Language:

english

File:

PDF, 1.09 MB

english, 2008

27

Growth hormone signalling: sprouting links between pathways, human genetics and therapeutic options

Iwona Pilecka, Andrew Whatmore, Rob Hooft van Huijsduijnen, Benoit Destenaves, Peter Clayton

Journal:

Trends in Endocrinology & Metabolism

Year:

2007

Language:

english

File:

PDF, 603 KB

english, 2007

28

Reduction of heart failure by pharmacological inhibition or gene deletion of protein tyrosine phosphatase 1B

Elodie Gomez, Magali Vercauteren, Baptiste Kurtz, Antoine Ouvrard-Pascaud, Paul Mulder, Jean-Paul Henry, Marie Besnier, Aurélie Waget, Rob Hooft Van Huijsduijnen, Michel L. Tremblay, Remy Burcelin, Ch

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2012

Language:

english

File:

PDF, 828 KB

english, 2012

29

Applying the SPOT peptide synthesis procedure to the study of protein tyrosine phosphatase substrate specificity: probing for the heavenly match in vitro

Xavier Espanel, Rob Hooft van Huijsduijnen

Journal:

Year:

2005

Language:

english

File:

PDF, 786 KB

english, 2005

30

MetaBlasts: tracing protein tyrosine phosphatase gene family roots from Man to Drosophila melanogaster and Caenorhabditis elegans genomes

Sebastien Wälchli, Jacques Colinge, Rob Hooft van Huijsduijnen

Journal:

Year:

2000

Language:

english

File:

PDF, 1.93 MB

english, 2000

31

ADAM 20 and 21; two novel human testis-specific membrane metalloproteases with similarity to fertilin-α

Rob Hooft van Huijsduijnen

Journal:

Year:

1998

Language:

english

File:

PDF, 906 KB

english, 1998

32

Protein tyrosine phosphatases: counting the trees in the forest

Rob Hooft van Huijsduijnen

Journal:

Year:

1998

Language:

english

File:

PDF, 6.80 MB

english, 1998

33

21-P042 Receptor protein tyrosine phosphatases as potential regulators of neurotrophin receptors in developing sensory neurons

Viktoria Tchetchelnitski, Monique van den Eijnden, Rob Hooft van Huijsduijnen, Andrew Stoker

Journal:

Mechanisms of Development

Year:

2009

Language:

english

File:

PDF, 37 KB

english, 2009

34

Expression of protein-tyrosine phosphatases in Acute Myeloid Leukemia cells:FLT3 ITD sustains high levels of DUSP6 expression

Deepika Arora, Susanne Köthe, Monique van den Eijnden, Rob Hooft van Huijsduijnen, Florian Heidel, Thomas Fischer, Sebastian Scholl, Benjamin Tölle, Sylvia-Annette Böhmer, Johan Lennartsson, Fabienne

Journal:

Cell Communication and Signaling

Year:

2012

Language:

english

File:

PDF, 536 KB

english, 2012

35

Designing the next generation of medicines for malaria control and eradication

Jeremy N Burrows, Rob Hooft van Huijsduijnen, Jörg J Möhrle…

Journal:

Malaria Journal

Year:

2013

Language:

english

File:

PDF, 871 KB

english, 2013

36

One subunit of the transcription factor NF-Y maps close to the major histocompatibility complex in murine and human chromosomes

Li, X-Y., Mattei, M.G., Zaleska-Rutczynska, Z., van Huijsduijnen, R.Hooft, Figueroa, F., Nadeau, J., Benoist, C., Mathis, D.

Journal:

Year:

1991

Language:

english

File:

PDF, 2.29 MB

english, 1991

37

Inhibition of protein tyrosine phosphatases enhances cerebral collateral growth in rats

Buschmann, Ivo, Hackbusch, Daniel, Gatzke, Nora, Dülsner, André, Trappiel, Manuela, Dagnell, Markus, Östman, Arne, van Huijsduijnen, Rob Hooft, Kappert, Kai

Journal:

Journal of Molecular Medicine

Year:

2014

Language:

english

File:

PDF, 3.07 MB

english, 2014

38

Protein tyrosine phosphatases as drug targets: PTP1B and beyond

Huijsduijnen, Rob Hooft van, Wälchli, Sébastien, Ibberson, Mark, Harrenga, Axel

Journal:

Expert Opinion on Therapeutic Targets

Year:

2002

Language:

english

File:

PDF, 213 KB

english, 2002

39

Conditional up-regulation of MHC class I in skeletal muscle leads to self-sustaining autoimmune myositis and myositis-specific autoantibodies

Nagaraju, K., Raben, N., Loeffler, L., Parker, T., Rochon, P. J., Lee, E., Danning, C., Wada, R., Thompson, C., Bahtiyar, G., Craft, J., Hooft van Huijsduijnen, R., Plotz, P.

Journal:

Proceedings of the National Academy of Sciences

Year:

2000

Language:

english

File:

PDF, 343 KB

english, 2000

40

Response to Letter Regarding Article, "Improvement of Peripheral Endothelial Dysfunction by Protein Tyrosine Phosphatase Inhibitors in Heart Failure"

Vercauteren, M., Remy, E., Devaux, C., Dautreaux, B., Henry, J.-P., Bauer, F., Mulder, P., Thuillez, C., Richard, V., Hooft van Huijsduijnen, R., Bombrun, A.

Journal:

Year:

2007

Language:

english

File:

PDF, 31 KB

english, 2007

41

Malaria medicines: a glass half full?

Wells, Timothy N. C., van Huijsduijnen, Rob Hooft, Van Voorhis, Wesley C.

Journal:

Nature Reviews Drug Discovery

Year:

2015

Language:

english

File:

PDF, 678 KB

english, 2015

42

Mapping of Synergistic Components of Weakly Interacting Protein-Protein Motifs Using Arrays of Paired Peptides

Espanel, X., Walchli, S., Ruckle, T., Harrenga, A., Huguenin-Reggiani, M., Hooft van Huijsduijnen, R.

Journal:

Journal of Biological Chemistry

Year:

2003

Language:

english

File:

PDF, 513 KB

english, 2003

43

Anticancer Properties of Distinct Antimalarial Drug Classes

Hooft van Huijsduijnen, Rob, Guy, R. Kiplin, Chibale, Kelly, Haynes, Richard K., Peitz, Ingmar, Kelter, Gerhard, Phillips, Margaret A., Vennerstrom, Jonathan L., Yuthavong, Yongyuth, Wells, Timothy N.

Journal:

Year:

2013

Language:

english

File:

PDF, 3.51 MB

english, 2013

44

Evolutionary variation of the CCAAT-binding transcription factor NF-Y

Li, X.-Y., Mantovani, R., van Huijsduijnen, R. Hooft, Andre, L., Benoist, C., Mathis, D.

Journal:

Nucleic Acids Research

Year:

1992

Language:

english

File:

PDF, 31 KB

english, 1992

45

Evolutionary variation of the CCAAT-binding transcription factor NF-Y

Li, Xiao-Yan, Mantovani, Roberto, Hooft van Huijsduijnen, Rob, Andre, Isabelle, Benoist, Christophe, Mathis, Diane

Journal:

Nucleic Acids Research

Year:

1992

Language:

english

File:

PDF, 442 KB

english, 1992

46

Properties of a CCAAT box-binding protein

van Huijsduijnen, R.A.M.Hooft, Bollekens, J., Dom, A., Benoist, C., Mathis, D.

Journal:

Nucleic Acids Research

Year:

1987

Language:

english

File:

PDF, 4.41 MB

english, 1987

47

Ferroquine: welcome to the next generation of antimalarials

Wells, Timothy NC, van Huijsduijnen, Rob Hooft

Journal:

The Lancet Infectious Diseases

Year:

2015

Language:

english

File:

PDF, 90 KB

english, 2015

48

12/15-lipoxygenase–derived lipid peroxides control receptor tyrosine kinase signaling through oxidation of protein tyrosine phosphatases

Marcus Conrad, Åsa Sandin, Heidi Förster, Alexander Seiler, Jeroen Frijhoff, Markus Dagnell, Georg W. Bornkamm, Olof Rådmark, Rob Hooft van Huijsduijnen, Pontus Aspenström, Frank Böhmer, Arne Östman a

Journal:

Proceedings of the National Academy of Sciences

Year:

2010

Language:

english

File:

PDF, 1.23 MB

english, 2010

49

RZRs, a new family of retinoid-related orphan receptors that function as both monomers and homodimers.

Carlberg, C, Hooft van Huijsduijnen, R, Staple, J K, DeLamarter, J F, Becker-André, M

Journal:

Molecular Endocrinology

Year:

1994

Language:

english

File:

PDF, 2.66 MB

english, 1994

50

Improvement of Peripheral Endothelial Dysfunction by Protein Tyrosine Phosphatase Inhibitors in Heart Failure

Vercauteren, M., Remy, E., Devaux, C., Dautreaux, B., Henry, J.-P., Bauer, F., Mulder, P., Hooft van Huijsduijnen, R., Bombrun, A., Thuillez, C., Richard, V.

Journal:

Year:

2006

Language:

english

File:

PDF, 715 KB

english, 2006

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